What diseases can be studied using this antibody targeting TNFSF4?

TNFSF4, also known as OX40L, is involved in various immune-mediated conditions. The antibody can be used in studies related to autoimmune diseases, inflammatory disorders, and cancer immunology.

Are there conjugation options available for this antibody?

It is available unconjugated, but custom conjugation options can be requested to suit various experimental setups, including fluorescent and biotin labels.

Mouse Anti-TNFSF4 Recombinant Antibody (clone R4930)

CAT#: NEUT-2204CQ

This antibody is a mouse monoclonal antibody that binds specifically to OX40L, and it can neutralize the bioactivity of OX40L.

Gene Expression Tested Data

Subcellular Location Figure 1 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm & vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/1331_F5_1_selected.jpg

Normal Tissue Figure 2 IHC staining of human tonsil

Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in non-germinal center cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/134109_A_4_8_selected.jpg

Normal Tissue Figure 3 Duodenum

Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/134109_A_8_2.jpg

Normal Tissue Figure 4 Colon

Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/134109_A_9_3.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/134109_A_6_6.jpg

Normal Tissue Figure 6 Lymph node

Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/134109_A_8_8.jpg

RNA Expression Figure 7 RNA cell line category: Cell line enhanced (fHDF/TERT166, HHSteC, HUVEC TERT2, LHCN-M2)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000117586-TNFSF4

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SDS-PAGE

Figure 1 Mouse Anti-TNFSF4 Recombinant Antibody (NEUT-2204CQ) in SDS-PAGE

SDS-PAGE analysis of NEUT-2204CQ in non-reduced (Lane 1) and reduced (Lane 2) conditions. Gel stained for 30 minutes with Coomassie Blue. As a result of different β-mercaptoethanol-reduced proteins (Heavy chain and Light chain) migrate as about 50 kDa and 25 kDa, respectively.

Figure 2 Mouse Anti-TNFSF4 Recombinant Antibody (NEUT-2204CQ) in DB

Dot blot analysis of NEUT-2204CQ was performed by loading Human OX40 Ligand / TNFSF4 Protein, active trimer (His Tag).

NEUT-2204CQ incubation concentration: 2 ng/μL.
The secondary antibody: HRP-Anti-Mouse IgG (H+L)

Figure 3 Mouse Anti-TNFSF4 Recombinant Antibody (NEUT-2204CQ) in WB

Western blot analysis of NEUT-2204CQ was performed by loading Human OX40 Ligand / TNFSF4 Protein, active trimer (His Tag).

NEUT-2204CQ incubation concentration: 2 ng/μL.
The secondary antibody: HRP-Anti-Mouse IgG (H+L)
Lane 1: Reducing antigen (0.1 μg)
Lane 2: Reducing antigen (0.3 μg)
Lane 3: Reducing antigen (0.6 μg)

ELISA

Figure 4 Mouse Anti-TNFSF4 Recombinant Antibody (NEUT-2204CQ) in ELISA

ELISA analysis of NEUT-2204CQ was performed by coating with Human OX40 Ligand / TNFSF4 Protein, active trimer (His tag).

The secondary antibody: HRP-Anti-Mouse IgG (H+L)

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Specifications

Immunogen
Human OX40L, the ligand of OX40

Host Species
Mouse

Type
Mouse IgG, κ

Specificity
Human TNFSF4

Species Reactivity
Human

Clone
R4930

Applications
FC, Block

Conjugate
Unconjugated

Product Property

Purification
Affinity purified

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
TNFSF4; TNF superfamily member 4; GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TNLG2B

Gene ID
7292

UniProt ID
P23510

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Breast cancer biomarkers at key points during disease progression

High Sensitivity in Detection

We have observed remarkable sensitivity in TNFSF4 detection, facilitating the precise quantification of expression levels across different conditions. This sensitivity is crucial for the subtle changes we are investigating.

Great Performance in Functional Assays

The utility of the Anti-TNFSF4 antibody in functional assays has been instrumental, allowing us to dissect complex signaling pathways during immune responses. Its consistent performance enhances the credibility of our findings.

Q&As

What diseases can be studied using this antibody targeting TNFSF4?

A: TNFSF4, also known as OX40L, is involved in various immune-mediated conditions. The antibody can be used in studies related to autoimmune diseases, inflammatory disorders, and cancer immunology.
Are there conjugation options available for this antibody?

A: It is available unconjugated, but custom conjugation options can be requested to suit various experimental setups, including fluorescent and biotin labels.

View the frequently asked questions answered by Creative Biolabs Support.

Cite This Product

To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# NEUT-2204CQ, RRID: AB_3111565)

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - NEUT-2204CQ.pdf

MSDS

MSDS - NEUT-2204CQ.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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TAB-0897CL-S(P)	Human Anti-TNFSF4 Recombinant Antibody; scFv Fragment (TAB-0897CL-S(P))	FC	Human scFv
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TAB-0900CL-S(P)	Human Anti-TNFSF4 Recombinant Antibody; scFv Fragment (TAB-0900CL-S(P))	FC	Human scFv
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NEUT-2198CQ	Rat Anti-Tnfsf4 Recombinant Antibody (NEUT-2198CQ)	Block, FC, IHC-Fr	Rat IgG2
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NEUT-2200CQ	Rat Anti-Tnfsf4 Recombinant Antibody (clone CBL346)	Neut, WB	Rat IgG2a
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CAT	Product Name	Application	Type
HPAB-0144-CN-F(E)	Mouse Anti-TNFSF4 Recombinant Antibody; Fab Fragment (HPAB-0144-CN-F(E))	ELISA, FC	Mouse Fab
HPAB-0145-CN-F(E)	Mouse Anti-TNFSF4 Recombinant Antibody; Fab Fragment (HPAB-0145-CN-F(E))	ELISA, FC	Mouse Fab
HPAB-0146-CN-F(E)	Human Anti-TNFSF4 Recombinant Antibody; Fab Fragment (HPAB-0146-CN-F(E))	ELISA, FC	Human Fab
HPAB-0147-CN-F(E)	Human Anti-TNFSF4 Recombinant Antibody; Fab Fragment (HPAB-0147-CN-F(E))	ELISA, FC	Human Fab
HPAB-0148-CN-F(E)	Human Anti-TNFSF4 Recombinant Antibody; Fab Fragment (HPAB-0148-CN-F(E))	ELISA, FC	Human Fab

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